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Stem Cells International
Volume 2016 (2016), Article ID 1728278, 9 pages
http://dx.doi.org/10.1155/2016/1728278
Review Article

The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals

1Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang 330031, China
2Faculty of Basic Medical Science, Jiangxi Medical College, Nanchang University, Nanchang 330031, China
3College of Life Science, Chinese PLA General Hospital, Beijing 100039, China
4The Second Affiliated Hospital of Nanchang University, Nanchang University, Nanchang 330006, China

Received 3 May 2015; Revised 4 August 2015; Accepted 11 August 2015

Academic Editor: Heinrich Sauer

Copyright © 2016 Zezheng Pan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The conventional view is that female mammals lose their ability to generate new germ cells after birth. However, in recent years, researchers have successfully isolated and cultured a type of germ cell from postnatal ovaries in a variety of mammalian species that have the abilities of self-proliferation and differentiation into oocytes, and this finding indicates that putative germline stem cells maybe exist in the postnatal mammalian ovaries. Herein, we review the research history and discovery of putative female germline stem cells, the concept that putative germline stem cells exist in the postnatal mammalian ovary, and the research progress, challenge, and application of putative germline stem cells in recent years.