Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy

Figure 3

Strategies proposed for neutralization of the CSC quiescent phenotype involved in treatment resistance. Three strategies have been proposed to neutralize the quiescent CSC-state. Induction of CSC entry into the cell cycle would sensitize cells to antiproliferating agents. Blocking quiescent CSCs in G0 was proposed as an alternative for preventing new tumor growth. Targeting CSCs in the quiescent state was also proposed for the elimination of this particular CSC subpopulation. CSC: cancer stem cell. Figure was constructed in part with objects from Servier Medical Art documents under license from Creative Commons Attribution 3.0 France (http://creativecommons.org/licenses/by/3.0/fr/legalcode).