Long Noncoding RNA Regulation of Pluripotency

Table 1

lncRNA transcripts expressed in ESCs and controlling pluripotency.

lncRNA	Species	Proposed role in ESCs pluripotency	References
AK028326 (GOMAFU/MIAT)	m	Oct4-activated lncRNA which controls Oct-4 expression by a feedback loop.	[38]
AK141205	m	Nanog-repressed lncRNA; AK141205 positively regulates Oct4 expression.	[38]
ES1, ES2, ES3	h	Oct4 and Nanog transcriptional targets. ES1-3 act as modular scaffold for PRC2 and SOX2.	[40]
MEG3/GTL2	m, h	Facilitates PRC2/JARID2 complex recruitment on target genes.	[47]
lincRNA-1592, lincRNA-1552	m	Bind WDR5/MLL1 complex and are necessary for Nanog and Oct4 expression.	[52]
MIRA	m	Facilitates WDR5/MLL1 complex recruitment on chromatin.	[55]
TUNA/MEGAMIND	m	Activates transcription of Nanog, Sox2, and Fgf4.	[42]
pRNA	m	Recruits TIP5 on rDNA upon differentiation.	[56]
linc-RoR	h	Acts as a sponge for miR-145.	[60]
lincRNA-p21	h	Interacts with HNRNPK to form a repressive complex at the promoter of key pluripotency regulators.	[62]
Dum	m	Favours DNA methylation at CpG sites at the promoter of the pluripotency-associated Dppa2.	[65]

Species: m = mouse; h = human.