Review Article
Endothelial Progenitor Cells in Diabetic Microvascular Complications: Friends or Foes?
Table 1
Overview of the effect of antidiabetic drugs on EPCs number and function.
| Author | Drug | Groups | Conclusion |
| Sorrentino et al., 2007 | Thiazolidinedione (TZD) | T2DM patients T2DM: Controls: | Rosiglitazone restored nitric oxide bioavailability and improved EPC function |
| Spigoni et al., 2012 | Thiazolidinedione (TZD) | In vitro cultured ECFC isolated from subjects with impaired glucose tolerance: | Pioglitazone improved ECFC viability and capacity to form tubular-like structures |
| Humpert et al., 2008 | Insulin | ECFC culture, in vitro | Insulin improved EPC function |
| Fadini et al., 2011 | Insulin | T2DM patients:
| Insulin increased EPC count |
| Maiorino et al., 2016 | Insulin | T1DM patients insulin infusion: | Insulin infusion increased EPC number in T1DM patients |
| Liao et al., 2010 |
Metformin | Newly diagnosed T2DM: Non-DM: |
Metformin increased EPC number in the blood |
| Liu et al., 2011 [62] | GLP-1 agonists | EPC culture, in vitro | GLP-1 enhanced EPC proliferation and VEGF production in EPC |
|
Gonçalves et al., 2012 | DPP-4 inhibitors | Diabetic rats | Sitagliptin increased the number of CD34+ cells in the blood |
|
Mohler III et al., 2009 | Atorvastatin; ezetimibe | Diabetic swines | EPC number in the circulation was increased by atorvastatin |
| Chang et al., 2010 | Adiponectin | Adiponectin deficient db/db mice | Adiponectin rescued EPC senescence |
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