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Stem Cells International
Volume 2016 (2016), Article ID 1894782, 10 pages
http://dx.doi.org/10.1155/2016/1894782
Research Article

Cancer Stem Cell Signaling during Repopulation in Head and Neck Cancer

1Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48703, USA
2Beaumont BioBank, William Beaumont Hospital, Royal Oak, MI 48703, USA
3Department of Human Oncology, University of Wisconsin Carbone Cancer Center, Madison, WI 53792, USA
4Department of Otolaryngology, William Beaumont Hospital, Royal Oak, MI 48703, USA
5Department of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA

Received 8 July 2015; Revised 7 October 2015; Accepted 15 November 2015

Academic Editor: Ahmad Waseem

Copyright © 2016 George D. Wilson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J.-P. Pignon, A. L. Maître, E. Maillard, and J. Bourhis, “Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients,” Radiotherapy and Oncology, vol. 92, no. 1, pp. 4–14, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Bryne, M. Boysen, C. G. Alfsen et al., “The invasive front of carcinomas. The most important area for tumour prognosis?” Anticancer Research, vol. 18, no. 6, pp. 4757–4764, 1998. View at Google Scholar · View at Scopus
  3. S. C. Tremmel, K. Götte, S. Popp et al., “Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization,” Cancer Genetics and Cytogenetics, vol. 144, no. 2, pp. 165–174, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. M. P. Tabor, R. H. Brakenhoff, V. M. M. Van Houten et al., “Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications,” Clinical Cancer Research, vol. 7, no. 6, pp. 1523–1532, 2001. View at Google Scholar · View at Scopus
  5. T. Reya, S. J. Morrison, M. F. Clarke, and I. L. Weissman, “Stem cells, cancer, and cancer stem cells,” Nature, vol. 414, no. 6859, pp. 105–111, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. Y.-C. Chen, Y.-W. Chen, H.-S. Hsu et al., “Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer,” Biochemical and Biophysical Research Communications, vol. 385, no. 3, pp. 307–313, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. Z. G. Chen, “The cancer stem cell concept in progression of head and neck cancer,” Journal of Oncology, vol. 2009, Article ID 894064, 8 pages, 2009. View at Publisher · View at Google Scholar
  8. M. R. Loebinger, A. Giangreco, K. R. Groot et al., “Squamous cell cancers contain a side population of stem-like cells that are made chemosensitive by ABC transporter blockade,” British Journal of Cancer, vol. 98, no. 2, pp. 380–387, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Pries, N. Wittkopf, T. Trenkle, S. M. Nitsch, and B. Wollenberg, “Potential stem cell marker CD44 is constitutively expressed in permanent cell lines of head and neck cancer,” In Vivo, vol. 22, no. 1, pp. 89–92, 2008. View at Google Scholar · View at Scopus
  10. M. E. Prince, R. Sivanandan, A. Kaczorowski et al., “Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 3, pp. 973–978, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Zhang, Y. Zhang, L. Mao, Z. Zhang, and W. Chen, “Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes,” Cancer Letters, vol. 277, no. 2, pp. 227–234, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. W. A. Woodward, M. S. Chen, F. Behbod, M. P. Alfaro, T. A. Buchholz, and J. M. Rosen, “WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 2, pp. 618–623, 2007. View at Google Scholar
  13. T. M. Phillips, W. H. McBride, and F. Pajonk, “The response of CD24−/low/CD44+ breast cancer-initiating cells to radiation,” Journal of the National Cancer Institute, vol. 98, no. 24, pp. 1777–1785, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Hambardzumyan, O. J. Becher, M. K. Rosenblum, P. P. Pandolfi, K. Manova-Todorova, and E. C. Holland, “PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo,” Genes and Development, vol. 22, no. 4, pp. 436–448, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Bao, Q. Wu, R. E. McLendon et al., “Glioma stem cells promote radioresistance by preferential activation of the DNA damage response,” Nature, vol. 444, no. 7120, pp. 756–760, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Facompre, H. Nakagawa, M. Herlyn, and D. Basu, “Stem-like cells and therapy resistance in squamous cell carcinomas,” Advances in Pharmacology, vol. 65, pp. 235–265, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Huang, J. L. Chunta, M. Amin et al., “Detailed characterization of the early response of head-neck cancer xenografts to irradiation using 18F-FDG-PET imaging,” International Journal of Radiation Oncology, Biology, Physics, vol. 84, no. 2, pp. 485–491, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Subramanian, P. Tamayo, V. K. Mootha et al., “Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 43, pp. 15545–15550, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Nikitin, S. Egorov, N. Daraselia, and I. Mazo, “Pathway studio—the analysis and navigation of molecular networks,” Bioinformatics, vol. 19, no. 16, pp. 2155–2157, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Kotelnikova, N. Ivanikova, A. Kalinin, A. Yuryev, and N. Daraselia, “Atlas of signaling for interpretation of microarray experiments,” PLoS ONE, vol. 5, no. 2, Article ID e9256, 2010. View at Publisher · View at Google Scholar
  21. S. Novichkova, S. Egorov, and N. Daraselia, “MedScan, a natural language processing engine for MEDLINE abstracts,” Bioinformatics, vol. 19, no. 13, pp. 1699–1706, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Yuryev, Z. Mulyukov, E. Kotelnikova et al., “Automatic pathway building in biological association networks,” BMC Bioinformatics, vol. 7, article 171, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Bhaijee, D. J. Pepper, K. T. Pitman, and D. Bell, “Cancer stem cells in head and neck squamous cell carcinoma: a review of current knowledge and future applications,” Head & Neck, vol. 34, no. 6, pp. 894–899, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Chen, J. Zhou, J. Lu, H. Xiong, X. Shi, and L. Gong, “Significance of CD44 expression in head and neck cancer: a systemic review and meta-analysis,” BMC Cancer, vol. 14, article 15, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. G. F. Huber, A. Albinger-Hegyi, A. Soltermann et al., “Expression patterns of Bmi-1 and p16 significantly correlate with overall, disease-specific, and recurrence-free survival in oropharyngeal squamous cell carcinoma,” Cancer, vol. 117, no. 20, pp. 4659–4670, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. A. M. Baschnagel, L. Williams, A. Hanna et al., “c-met expression is a marker of poor prognosis in patients with locally advanced head and neck squamous cell carcinoma treated with chemoradiation,” International Journal of Radiation Oncology Biology Physics, vol. 88, no. 3, pp. 701–707, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. D. Li, P. Dong, C. Wu, P. Cao, and L. Zhou, “Notch1 overexpression associates with poor prognosis in human laryngeal squamous cell carcinoma,” Annals of Otology, Rhinology & Laryngology, vol. 123, no. 10, pp. 705–710, 2014. View at Google Scholar
  28. C. Zhou and B. Sun, “The prognostic role of the cancer stem cell marker aldehyde dehydrogenase 1 in head and neck squamous cell carcinomas: a meta-analysis,” Oral Oncology, vol. 50, no. 12, pp. 1144–1148, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Schröck, M. Bode, F. J. M. Göke et al., “Expression and role of the embryonic protein SOX2 in head and neck squamous cell carcinoma,” Carcinogenesis, vol. 35, no. 7, Article ID bgu094, pp. 1636–1642, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Trapasso and E. Allegra, “Role of CD44 as a marker of cancer stem cells in head and neck cancer,” Biologics: Targets and Therapy, vol. 6, pp. 379–383, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Faber, C. Barth, K. Hörmann et al., “CD44 as a stem cell marker in head and neck squamous cell carcinoma,” Oncology Reports, vol. 26, no. 2, pp. 321–326, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. X. Qian, S. Wagner, C. Ma et al., “Prognostic significance of ALDH1A1-positive cancer stem cells in patients with locally advanced, metastasized head and neck squamous cell carcinoma,” Journal of Cancer Research and Clinical Oncology, vol. 140, no. 7, pp. 1151–1158, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Krishnamurthy, Z. Dong, D. Vodopyanov et al., “Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells,” Cancer Research, vol. 70, no. 23, pp. 9969–9978, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. M.-J. De Herdt and R. J. Baatenburg de Jong, “HGF and c-MET as potential orchestrators of invasive growth in head and neck squamous cell carcinoma,” Frontiers in Bioscience, vol. 13, no. 7, pp. 2516–2526, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Sun and Z. Wang, “Head neck squamous cell carcinoma c-Met+ cells display cancer stem cell properties and are responsible for cisplatin-resistance and metastasis,” International Journal of Cancer, vol. 129, no. 10, pp. 2337–2348, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. Y. S. Brooks, P. Ostano, S. H. Jo et al., “Multifactorial ERβ and NOTCH1 control of squamous differentiation and cancer,” The Journal of Clinical Investigation, vol. 124, no. 5, pp. 2260–2276, 2014. View at Publisher · View at Google Scholar
  37. S. H. Lee, H. S. Hong, Z. X. Liu et al., “TNFalpha enhances cancer stem cell-like phenotype via Notch-Hes1 activation in oral squamous cell carcinoma cells,” Biochemical and Biophysical Research Communications, vol. 424, no. 1, pp. 58–64, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. K. Chikamatsu, H. Ishii, G. Takahashi et al., “Resistance to apoptosis-inducing stimuli in CD44+ head and neck squamous cell carcinoma cells,” Head and Neck, vol. 34, no. 3, pp. 336–343, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. Q. Zhang, S. Shi, Y. Yen, J. Brown, J. Q. Ta, and A. D. Le, “A subpopulation of CD133+ cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy,” Cancer Letters, vol. 289, no. 2, pp. 151–160, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. E. Allegra, S. Trapasso, D. Pisani, and L. Puzzo, “The role of BMI1 as a biomarker of cancer stem cells in head and neck cancer: a review,” Oncology, vol. 86, no. 4, pp. 199–205, 2014. View at Publisher · View at Google Scholar · View at Scopus
  41. L. A. Boyer, I. L. Tong, M. F. Cole et al., “Core transcriptional regulatory circuitry in human embryonic stem cells,” Cell, vol. 122, no. 6, pp. 947–956, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. Y. C. Lim, S.-Y. Oh, Y. Y. Cha, S.-H. Kim, X. Jin, and H. Kim, “Cancer stem cell traits in squamospheres derived from primary head and neck squamous cell carcinomas,” Oral Oncology, vol. 47, no. 2, pp. 83–91, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. H. R. Withers, J. M. G. Taylor, and B. Maciejewski, “The hazard of accelerated tumor clonogen repopulation during radiotherapy,” Acta Oncologica, vol. 27, no. 2, pp. 131–146, 1988. View at Publisher · View at Google Scholar · View at Scopus
  44. T. Nishioka, M. Yasuda, T. Takeshima et al., “Radiation-induced cancer cell repopulation: a possible mechanism implied by experiments using transplantable mouse-derived sarcoma cell line,” Cell Structure and Function, vol. 36, no. 1, pp. 13–20, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. Q. Huang, F. Li, X. Liu et al., “Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy,” Nature Medicine, vol. 17, no. 7, pp. 860–866, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. I. Espinoza, R. Pochampally, F. Xing, K. Watabe, and L. Miele, “Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition,” OncoTargets and Therapy, vol. 6, pp. 1249–1259, 2013. View at Publisher · View at Google Scholar · View at Scopus
  47. P. S. Satpute, V. Hazarey, R. Ahmed, and L. Yadav, “Cancer stem cells in head and neck squamous cell carcinoma: a review,” Asian Pacific Journal of Cancer Prevention, vol. 14, no. 10, pp. 5579–5587, 2013. View at Publisher · View at Google Scholar · View at Scopus
  48. M. R. Clay, M. Tabor, J. H. Owen et al., “Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase,” Head and Neck, vol. 32, no. 9, pp. 1195–1201, 2010. View at Publisher · View at Google Scholar · View at Scopus
  49. C. Visus, Y. Wang, A. Lozano-Leon et al., “Targeting ALDHbright human carcinoma-initiating cells with ALDH1A1-specific CD8+ T cells,” Clinical Cancer Research, vol. 17, no. 19, pp. 6174–6184, 2011. View at Publisher · View at Google Scholar · View at Scopus
  50. Y. C. Lim, H. J. Kang, and J. H. Moon, “C-Met pathway promotes self-renewal and tumorigenecity of head and neck squamous cell carcinoma stem-like cell,” Oral Oncology, vol. 50, no. 7, pp. 633–639, 2014. View at Publisher · View at Google Scholar · View at Scopus
  51. S. H. Hong, F. G. Ondrey, I. M. Avis et al., “Cyclooxygenase regulates human oropharyngeal carcinomas via the proinflammatory cytokine IL-6: a general role for inflammation?” The FASEB Journal, vol. 14, no. 11, pp. 1499–1507, 2000. View at Publisher · View at Google Scholar · View at Scopus