Cancer Stem Cell Signaling during Repopulation in Head and Neck Cancer

Table 1

Genes differentially expressed ( and 1.5-fold) at a minimum of one time point in UT-SCC-14 xenografts after radiation.

Gene		Day 4		Day 7		Day 12		Day 21
		↑	↓	↑	↓	↑	↓	↑	↑
CD44	62	5	3	20	12	28	11	3	4
ALDH	9	2	0	2	4	3	1	1	1
MET	48	7	1	16	8	25	9	4	5
OCT3/4	37	6	1	10	5	18	4	4	4
BMI1	16	1	0	2	7	6	1	0	1
NOTCH1	66	7	4	19	14	29	11	1	4
NANOG	29	5	2	7	4	15	4	4	3
SOX2	29	3	1	8	5	12	3	1	2
CD133	20	2	1	3	4	9	3	0	3
Total	316	38	13	87	63	145	47	18	27

Using Partek Genomics software and Pathway Studio, genes that were differentially expressed at a minimum of one time point after radiation with a value ≤ 0.01 and fold change (negative or positive) of 1.5 or greater were identified for each of the CSC-associated genes. For each gene, represents the total number of identified genes in each pathway whilst the ↑ and ↓ arrows for each day after radiation represent the number of genes which were upregulated or downregulated, respectively.