Research Article
Mesenchymal Stromal Cells Derived Extracellular Vesicles Ameliorate Acute Renal Ischemia Reperfusion Injury by Inhibition of Mitochondrial Fission through miR-30
Figure 2
hWJMSC-EVs deliver and restore the expression of miR-30 in injured renal tubular epithelial cells. (a) Representative quantitative reverse transcriptase- (qRT-) PCR analysis for miR-30b/c/d in kidney tissues 24 hours after sham, IRI, or EVs treatment. (b) qRT-PCR analysis of miR-30b/c/d content in EVs derived from MSCs cultured with vehicle alone (wild-type) or subjected to miR-30b/c/d antagomir. (c) miR-30b/c/d levels in kidney in different experimental conditions, including sham, vehicle, EVs, and miR-30b/c/d antagomir-treated EVs group. Data in (a) and (c) are presented as mean ± SD; ; , versus sham; , versus vehicle.
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