Modeling Neurological Disease by Rapid Conversion of Human Urine Cells into Functional Neurons

Figure 4

Membrane properties of the urine-iN cells. Whole cell recording was conducted on urine-iN cells identified by differential interference contrast microscopy. (a) Representative traces of membrane currents. Fast-activating and inactivating Na⁺ currents were prominent in all the iN cells. The Na⁺ currents could be blocked by tetrodotoxin (TTX). (b) Representative traces of action potentials in response to step current injections 35 days after induction. Membrane potential was maintained at approximately −52 mV. And the action potentials could be blocked by TTX treatment.

(a)

(b)