High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td align="left">Compounds</td><td align="center">MW</td><td align="center">
                  CAS number</td><td align="center">Therapeutic group/chemical class</td><td align="center">Mechanism of toxicity</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td align="left">Amiodarone HCl</td><td align="center">681.8</td><td align="center">19774-82-4</td><td align="center">Antiarrhythmic agent</td><td align="center">ST, PL, MI</td></tr><tr><td align="left">Doxycycline</td><td align="center">512.94</td><td align="center">24390-14-5</td><td align="center">Antibiotic</td><td align="center">MI, AP, ST</td></tr><tr><td align="left">Tetracycline hydrochloride</td><td align="center">480.9</td><td align="center">64-75-5</td><td align="center">Antibiotic</td><td align="center">ST, MI</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>AP: apoptosis; CAS: chemical abstracts service; MI: mitochondrial impairment; MW: molecular weight; PL: phospholipidosis; ST: steatosis.<br/></td></tr></table>

Compounds studied according to their documented mechanism of action.

Stem Cells International

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Table 1

Table 1: High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis 