Pharmacological Inhibition of Gal-3 in Mesenchymal Stem Cells Enhances Their Capacity to Promote Alternative Activation of Macrophages in Dextran Sulphate Sodium-Induced Colitis
MSCs attenuate DSS-induced colitis. Water with 3% DSS was given to mice for 7 days; regular drinking water was fed to control mice. The concentration of Gal-3 in sera of MSCs groups (a). Survival rate of mice with colitis (b). Disease Activity Index (DAI) scored at day 7 using the following parameters: weight loss, stool consistency, and rectal bleeding (c). After DSS treatment length of the entire colon was measured (d). Histological examination was performed with hematoxylin and eosin staining (e). H&E staining images of representative colon tissues are shown at the same magnifications (100x) (e). Data presented as means ± SEM; mice per experimental groups. , .