Pharmacological Inhibition of Gal-3 in Mesenchymal Stem Cells Enhances Their Capacity to Promote Alternative Activation of Macrophages in Dextran Sulphate Sodium-Induced Colitis
Pharmacological inhibition of Gal-3 in MSCs favored alternative activation of macrophages in the colon tissues of DSS-treated mice. The percentage of F4/80+ macrophages in colon tissue (a). Significant decrease in percentage of F4/80+CD206+ and F4/80+ IL-10+ macrophages in MSCs-treated mice (white bars), when compared to MSCs + Davanat-treated mice (black bars), after 7 days on DSS treatment (b and c). The percentage of IL-12- and IL-1β-producing F4/80+ macrophages (d and e). The percentages of inflammatory dendritic cells (f) and FcεRI+CD117+ mast cells (g) as well as CD3+NK1.1+NKT cells (h) are shown. Values are mean ± SEM ( per group). , .