LncRNAs in Stem Cells

Figure 1

Some known functional mechanisms of lncRNAs in stem cells. (a) Pnky localizes to the nucleus and interacts with the mRNA splicing regulator PTBP1 to regulate splicing of key transcripts; (b) some lncRNAs serve as cofactors of key transcription factors (TF) to regulate gene transcription; (c) Xist as an epigenetic regulator of X chromosome inactivation plays roles in female ESCs and iPSCs; (d) Blnc1 is activated by EBF2 and functions as a coactivator of EBF2; (e) linc-MD1 is the primary transcript of miR-133b and H19 is the primary transcript of miR-675, and the Drosha processing of both is regulated by HuR; (f) TINCR interacts with STAU1 and multiple mRNAs via an RNA motif called TINCR box; (g) linc-ROR functions as a mir-145 sponge.