MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs

Figure 3

MicroRNA profiling of hMB-SLCs and RA-treated cells and qPCR validation. (a) Heatmap with unsupervised hierarchical clustering was obtained for hMB-SLCs and their differentiated counterparts. Dendrogram which represents the results of the hierarchical clustering analysis distinguishes hMB-SLCs from RA-treated ones. (b) Significantly up- or downregulated microRNAs in hMB-SLCs versus RA-treated cells with the respective fold change and values are reported. (c) Single qPCR analysis of miR-195, miR-135b, and miR-145 was conducted. MicroRNAs expression levels are expressed as fold change with respect to hMB-SLCs. denotes versus hMB-SLCs. (d) Biological processes ranked according to the number of microRNAs involved in each process are assigned as in KEGG pathway.

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