Differential Proteomic Analysis of Human Placenta-Derived Mesenchymal Stem Cells Cultured on Normal Tissue Culture Surface and Hyaluronan-Coated Surface

<div>PDMSC underwent normal aging process without HA presence. (a) The aging phenomenon of PDMSC was hypothesized to be attenuated under HA presence. (b) HA was hypothesized to bind to its receptor with ankyrin repeat domain (KANK2) and suppressed the downstream actin-interacting proteins. (c) In absence of HA, the Ras signaling was hypothesized to have increased over long period of expansion and increased the downstream actin dynamics, focal adhesion kinase (FAK), stress fiber formation, and enhanced aging. Yellow boxes represented downregulation; orange boxes represented upregulation.</div>

Stem Cells International

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Figure 5

Figure 5: Differential Proteomic Analysis of Human Placenta-Derived Mesenchymal Stem Cells Cultured on Normal Tissue Culture Surface and Hyaluronan-Coated Surface 

Figure 5 | Differential Proteomic Analysis of Human Placenta-Derived Mesenchymal Stem Cells Cultured on Normal Tissue Culture Surface and Hyaluronan-Coated Surface 