Differential Proteomic Analysis of Human Placenta-Derived Mesenchymal Stem Cells Cultured on Normal Tissue Culture Surface and Hyaluronan-Coated Surface

Table 1

Structural maintenance and aging-related proteins. H, heavy; L, light.

Category	Protein IDs	Protein names	Gene name	Normalized ratio			Function	Reference
				H/L; SC [%]	H/L; SC [%]	H/L; SC [%]
				OTCS:YTCS	OCHA:OTCS	OCHA:YCHA
Structural	P20700	Lamin-B1	LMNB1	0.94787; (8.4)	1.1111; (8.9)	0.5203; (7.3)	Nuclear structure	[19]
Structural	Q8NF91	Nesprin-1	SYNE1	NA	2.5356; (0.4)	NA	Nuclear maintenance	STRING
Signal transduction	Q01995	Transgelin	TAGLN	2.0888; (65.2)	0.6132; (69.2)	1.0023; (51.7)	Replicative senescence	[20, 21]
Protein biosynthesis/degradation	P17096	High mobility group protein HMG-I/HMG-Y	HMGA1	0.86138; (23.4)	1.6148; (23.4)	1.063; (23.4)	Senescence, stemness	[22, 23]
Cell death	O00622	Protein CYR61	CYR61	1.0073; (22)	0.3514; (35.7)	NA	Senescence, survival	[24–26]
Protein folding/stress	Q9NQ88	Probable fructose-2,6-bisphosphatase TIGAR	TIGAR	0.59062; (13)	1.149; (13)	1.42; (13)	Senescence, stress-responsive	[27, 28]
Structural	Q13459	Unconventional myosin-IXb	MYO9B	0.4769; (1.3)	N/A	2.1214; (1.1)	Cytoskeletons. Rho-mediated signaling	[29, 30]
Structural	O95747	Serine/threonine- protein kinase OSR1	OXSR1	ND	ND	1.6339; (6.5)	Cytoskeletons. Stress- responsive, regulates actin	[31]
Signal transduction	P61587	Rho-related GTP-binding protein RhoE	RND3	1.5923; (10.2)	0.4502; (17.2)	ND	Cytoskeletons. Stress fiber formation, cell motility, and adhesion	[32–34]
Structural	Q9UHB6	LIM domain and actin-binding protein 1	LIMA1	1.5189; (15.3)	0.4547; (13.0)	0.6461; (7.6)	Cytoskeletons	[32]
Signal transduction	Q13642	Four and a half LIM domains protein 1	FHL1	3.2279; (24.1)	0.3981; (16.1)	1.2503; (12.7)	Cytoskeletons. Cardiac cell differentiation	[32]
Structural	O00151	PDZ and LIM domain protein 1	PDLIM1	1.5045; (37.1)	1.2779; (37.7)	1.4622; (27.4)	Cytoskeletons	[32]
Structural	P07197	Neurofilament medium polypeptide	NEFM	2.2981; (5.1)	0.4864; (9.4)	ND	Cytoskeletons. Protein transport in neuron cells, axonal growth.	[35]
Structural	P09493	Tropomyosin alpha-1 chain	TPM1	2.2465; (35.2)	0.6003; (26.1)	NA	Cytoskeletons. Cardiac muscle contraction	[36]
Structural	Q14315	Filamin-C	FLNC	1.6548; (19.6)	0.5924; (23.4)	1.2207; (15.3)	Cytoskeletons. Interacts with actin	STRING

Normalized ratio H/L reversed: 1/[H/L].
Sequence coverage %.
Not applicable.
Not detected.
Analyzed by STRING9.1.