Mesenchymal Stem Cells and Metabolic Syndrome: Current Understanding and Potential Clinical Implications

Figure 2

Schema of the clinical impact of MSC adipogenesis on metabolic syndrome. Pathophysiology of metabolic syndrome is quite complex and the precise mechanisms linking each condition remain unclear. Among the potential clinical applications of MSCs, studies assessing MSCs as a source of transplantation material in the treatment of diabetes have shown encouraging results. MSC-based therapeutic options for diabetes could be used in the clinical setting in the future. Although further studies are needed to elucidate the roles of MSCs and MSC adipogenesis in metabolic syndrome, MSC therapy is expected to become a new level of therapeutic option for this syndrome. DL, dyslipidemia; DM, diabetes mellitus; HTN, hypertension; LXRs, liver X receptors; MetS, metabolic syndrome; MSCs, mesenchymal stem cells; and RAS, renin-angiotensin system.