The Interaction between Adult Cardiac Fibroblasts and Embryonic Stem Cell-Derived Cardiomyocytes Leads to Proarrhythmic Changes in In Vitro Cocultures

Figure 3

Comparison of action potential parameters of aCF-ESC-CM and MSC-ESC-CM cocultures as well as control ESC-CMs. Representative AP waveforms of beating clusters of ESC-CMs (a) as well as cocultures of ESC-CMs with aCFs (b) or with MSCs (c). Maximal upstroke velocity () was reduced in cocultures with aCFs and MSCs (d) while action potential duration was only prolonged in cocultures of ESC-CMs with aCFs (e) compared to controls. Data are expressed as mean ± SEM;   .

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