The Interaction between Adult Cardiac Fibroblasts and Embryonic Stem Cell-Derived Cardiomyocytes Leads to Proarrhythmic Changes in In Vitro Cocultures

Figure 5

Effects of aCF-conditioned medium on action potential recordings of ESC-CMs. Representative AP waveforms of ESC-CM beating clusters cultured for 48 h in control medium (a) and aCF-conditioned medium (b). APD50 was prolonged (c). Maximal upstroke velocity () was not significantly reduced (d). Data are expressed as mean ± SEM; .

(a)

(b)

(c)

(d)