Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2016 (2016), Article ID 3146805, 12 pages
http://dx.doi.org/10.1155/2016/3146805
Research Article

The Regulatory Effects of Long Noncoding RNA-ANCR on Dental Tissue-Derived Stem Cells

1Institution of Stomatology, The PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China
2Department of Endodontics, Xiamen Stomatology Hospital, Teaching Hospital of Fujian Medical University, No. 1309 Lvling Road, Xiamen, Fujian 361003, China
3State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Operative Dentistry & Endodontics, School of Stomatology, Fourth Military Medical University, No. 145 Western Changle Road, Xi’an, Shaanxi 710032, China

Received 17 May 2016; Revised 6 July 2016; Accepted 10 July 2016

Academic Editor: Hung-Fat Tse

Copyright © 2016 Qian Jia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Gronthos, M. Mankani, J. Brahim, P. G. Robey, and S. Shi, “Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 25, pp. 13625–13630, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. B.-M. Seo, M. Miura, S. Gronthos et al., “Investigation of multipotent postnatal stem cells from human periodontal ligament,” The Lancet, vol. 364, no. 9429, pp. 149–155, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. W. Sonoyama, Y. Liu, T. Yamaza et al., “Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study,” Journal of Endodontics, vol. 34, no. 2, pp. 166–171, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Song, W. Jiang, A. Alraies et al., “Bladder smooth muscle cells differentiation from dental pulp stem cells: future potential for bladder tissue engineering,” Stem Cells International, vol. 2016, Article ID 6979368, 11 pages, 2016. View at Publisher · View at Google Scholar
  5. P. Hilkens, P. Gervois, Y. Fanton et al., “Effect of isolation methodology on stem cell properties and multilineage differentiation potential of human dental pulp stem cells,” Cell and Tissue Research, vol. 353, no. 1, pp. 65–78, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. B.-C. Kim, H. Bae, I.-K. Kwon et al., “Osteoblastic/cementoblastic and neural differentiation of dental stem cells and their applications to tissue engineering and regenerative medicine,” Tissue Engineering Part B: Reviews, vol. 18, no. 3, pp. 235–244, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. W. L. Dissanayaka, X. Zhan, C. Zhang, K. M. Hargreaves, L. Jin, and E. H. Y. Tong, “Coculture of dental pulp stem cells with endothelial cells enhances osteo-/odontogenic and angiogenic potential in vitro,” Journal of Endodontics, vol. 38, no. 4, pp. 454–463, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Janebodin, Y. Zeng, W. Buranaphatthana, N. Ieronimakis, and M. Reyes, “VEGFR2-dependent angiogenic capacity of pericyte-like dental pulp stem cells,” Journal of Dental Research, vol. 92, no. 6, pp. 524–531, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. W. Sonoyama, Y. Liu, D. Fang et al., “Mesenchymal stem cell-mediated functional tooth regeneration in swine,” PLoS ONE, vol. 1, no. 1, article e79, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Osathanon, N. Nowwarote, and P. Pavasant, “Basic fibroblast growth factor inhibits mineralization but induces neuronal differentiation by human dental pulp stem cells through a FGFR and PLCγ signaling pathway,” Journal of Cellular Biochemistry, vol. 112, no. 7, pp. 1807–1816, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. X. Feng, D. Huang, X. Lu et al., “Insulin-like growth factor 1 can promote proliferation and osteogenic differentiation of human dental pulp stem cells via mTOR pathway,” Development Growth and Differentiation, vol. 56, no. 9, pp. 615–624, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. W. He, Z. Wang, Z. Luo et al., “LPS promote the odontoblastic differentiation of human dental pulp stem cells via MAPK signaling pathway,” Journal of Cellular Physiology, vol. 230, no. 3, pp. 554–561, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. X. Yang, S. Zhang, X. Pang, and M. Fan, “Pro-inflammatory cytokines induce odontogenic differentiation of dental pulp-derived stem cells,” Journal of Cellular Biochemistry, vol. 113, no. 2, pp. 669–677, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. I. Gay, A. Cavender, D. Peto et al., “Differentiation of human dental stem cells reveals a role for microRNA-218,” Journal of Periodontal Research, vol. 49, no. 1, pp. 110–120, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. E. S. Hara, M. Ono, T. Eguchi et al., “MiRNA-720 controls stem cell phenotype, proliferation and differentiation of human dental pulp cells,” PLoS ONE, vol. 8, no. 12, article e83545, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. F. Wei, D. Liu, C. Feng et al., “MicroRNA-21 mediates stretch-induced osteogenic differentiation in human periodontal ligament stem cells,” Stem Cells and Development, vol. 24, no. 3, pp. 312–319, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Ye, C. Li, X. Xiang et al., “Bone morphogenetic protein-9 induces PDLSCs osteogenic differentiation through the ERK and p38 signal pathways,” International Journal of Medical Sciences, vol. 11, no. 10, pp. 1065–1072, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Osathanon, N. Nowwarote, J. Manokawinchoke, and P. Pavasant, “BFGF and JAGGED1 regulate alkaline phosphatase expression and mineralization in dental tissue-derived mesenchymal stem cells,” Journal of Cellular Biochemistry, vol. 114, no. 11, pp. 2551–2561, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. X. Chen, C. Hu, G. Wang et al., “Nuclear factor-κB modulates osteogenesis of periodontal ligament stem cells through competition with β-catenin signaling in inflammatory microenvironments,” Cell Death & Disease, vol. 4, no. 2, article e510, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. D.-S. Song, J.-C. Park, I.-H. Jung et al., “Enhanced adipogenic differentiation and reduced collagen synthesis induced by human periodontal ligament stem cells might underlie the negative effect of recombinant human bone morphogenetic protein-2 on periodontal regeneration,” Journal of Periodontal Research, vol. 46, no. 2, pp. 193–203, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Osathanon, J. Manokawinchoke, N. Nowwarote, P. Aguilar, T. Palaga, and P. Pavasant, “Notch signaling is involved in neurogenic commitment of human periodontal ligament-derived mesenchymal stem cells,” Stem Cells and Development, vol. 22, no. 8, pp. 1220–1231, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Wu, G. T.-J. Huang, W. He et al., “Basic fibroblast growth factor enhances stemness of human stem cells from the apical papilla,” Journal of Endodontics, vol. 38, no. 5, pp. 614–622, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Wang, B. Liu, S. Gu, and J. Liang, “Effects of Wnt/β-catenin signalling on proliferation and differentiation of apical papilla stem cells,” Cell Proliferation, vol. 45, no. 2, pp. 121–131, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. W. Zhang, X. Zhang, J. Ling et al., “Proliferation and odontogenic differentiation of BMP2 gene-transfected stem cells from human tooth apical papilla: An In Vitro Study,” International Journal of Molecular Medicine, vol. 34, no. 4, pp. 1004–1012, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. Li, M. Yan, Z. Wang et al., “17β-estradiol promotes the odonto/osteogenic differentiation of stem cells from apical papilla via mitogen-activated protein kinase pathway,” Stem Cell Research & Therapy, vol. 5, no. 6, p. 125, 2014. View at Google Scholar
  26. L. Lipovich, R. Johnson, and C.-Y. Lin, “MacroRNA underdogs in a microRNA world: evolutionary, regulatory, and biomedical significance of mammalian long non-protein-coding RNA,” Biochimica et Biophysica Acta (BBA)—Gene Regulatory Mechanisms, vol. 1799, no. 9, pp. 597–615, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Ponjavic, C. P. Ponting, and G. Lunter, “Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs,” Genome Research, vol. 17, no. 5, pp. 556–565, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. H. van Bakel, C. Nislow, B. J. Blencowe, and T. R. Hughes, “Most ‘dark matter’ transcripts are associated with known genes,” PLoS Biology, vol. 8, no. 5, article e1000371, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. M. E. Dinger, D. K. Gascoigne, and J. S. Mattick, “The evolution of RNAs with multiple functions,” Biochimie, vol. 93, no. 11, pp. 2013–2018, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. C. P. Ponting, P. L. Oliver, and W. Reik, “Evolution and functions of long noncoding RNAs,” Cell, vol. 136, no. 4, pp. 629–641, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Guttman, I. Amit, M. Garber et al., “Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals,” Nature, vol. 458, no. 7235, pp. 223–227, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Kretz, D. E. Webster, R. J. Flockhart et al., “Suppression of progenitor differentiation requires the long noncoding RNA ANCR,” Genes and Development, vol. 26, no. 4, pp. 338–343, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. L. Zhu and P.-C. Xu, “Downregulated LncRNA-ANCR promotes osteoblast differentiation by targeting EZH2 and regulating Runx2 expression,” Biochemical and Biophysical Research Communications, vol. 432, no. 4, pp. 612–617, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. Q. Jia, W. Jiang, and L. Ni, “Down-regulated non-coding RNA (lncRNA-ANCR) promotes osteogenic differentiation of periodontal ligament stem cells,” Archives of Oral Biology, vol. 60, no. 2, pp. 234–241, 2015. View at Publisher · View at Google Scholar · View at Scopus
  35. W. Jiang, H. Lv, H. Wang et al., “Activation of the NLRP3/caspase-1 inflammasome in human dental pulp tissue and human dental pulp fibroblasts,” Cell and Tissue Research, vol. 361, no. 2, pp. 541–555, 2015. View at Publisher · View at Google Scholar · View at Scopus
  36. W. Jiang, L. Ni, A. Sloan, and B. Song, “Tissue engineering and regenerative medicine, from and beyond the dentistry,” Dentistry, vol. 5, no. 6, article 306, 2015. View at Publisher · View at Google Scholar
  37. P. D. Potdar and Y. D. Jethmalani, “Human dental pulp stem cells: applications in future regenerative medicine,” World Journal of Stem Cells, vol. 7, no. 5, pp. 839–851, 2015. View at Publisher · View at Google Scholar
  38. N. K. Lee, H. Sowa, E. Hinoi et al., “Endocrine regulation of energy metabolism by the skeleton,” Cell, vol. 130, no. 3, pp. 456–469, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Mizuno and Y. Kuboki, “Osteoblast-related gene expression of bone marrow cells during the osteoblastic differentiation induced by type I collagen,” Journal of Biochemistry, vol. 129, no. 1, pp. 133–138, 2001. View at Publisher · View at Google Scholar · View at Scopus
  40. Y. Ogata, “Bone sialoprotein and its transcriptional regulatory mechanism,” Journal of Periodontal Research, vol. 43, no. 2, pp. 127–135, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. R. Siersbæk, R. Nielsen, and S. Mandrup, “PPARγ in adipocyte differentiation and metabolism—novel insights from genome-wide studies,” FEBS Letters, vol. 584, no. 15, pp. 3242–3249, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. B. Mead, A. Logan, M. Berry, W. Leadbeater, and B. A. Scheven, “Intravitreally transplanted dental pulp stem cells promote neuroprotection and axon regeneration of retinal ganglion cells after optic nerve injury,” Investigative Ophthalmology and Visual Science, vol. 54, no. 12, pp. 7544–7556, 2013. View at Publisher · View at Google Scholar · View at Scopus
  43. J.-S. Ryu, K. Ko, J.-W. Lee et al., “Gangliosides are involved in neural differentiation of human dental pulp-derived stem cells,” Biochemical and Biophysical Research Communications, vol. 387, no. 2, pp. 266–271, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. R. B. Bressan, F. R. Melo, P. A. Almeida et al., “EGF-FGF2 stimulates the proliferation and improves the neuronal commitment of mouse epidermal neural crest stem cells (EPI-NCSCs),” Experimental Cell Research, vol. 327, no. 1, pp. 37–47, 2014. View at Publisher · View at Google Scholar · View at Scopus
  45. E. Eleuterio, O. Trubiani, M. Sulpizio et al., “Proteome of human stem cells from periodontal ligament and dental pulp,” PLoS ONE, vol. 8, no. 8, Article ID e71101, 2013. View at Publisher · View at Google Scholar · View at Scopus
  46. P. Bianco and P. G. Robey, “Stem cells in tissue engineering,” Nature, vol. 414, no. 6859, pp. 118–121, 2001. View at Publisher · View at Google Scholar · View at Scopus
  47. E. Fuchs and J. A. Segre, “Stem cells: a new lease on life,” Cell, vol. 100, no. 1, pp. 143–155, 2000. View at Publisher · View at Google Scholar · View at Scopus
  48. K. A. Moore and I. R. Lemischka, “Stem cells and their niches,” Science, vol. 311, no. 5769, pp. 1880–1885, 2006. View at Publisher · View at Google Scholar · View at Scopus
  49. H. Løvschall, M. Tummers, I. Thesleff, E.-M. Füchtbauer, and K. Poulsen, “Activation of the Notch signaling pathway in response to pulp capping of rat molars,” European Journal of Oral Sciences, vol. 113, no. 4, pp. 312–317, 2005. View at Publisher · View at Google Scholar · View at Scopus
  50. C. Y. Logan and R. Nusse, “The Wnt signaling pathway in development and disease,” Annual Review of Cell and Developmental Biology, vol. 20, pp. 781–810, 2004. View at Publisher · View at Google Scholar · View at Scopus
  51. Y.-H. Chen, M.-C. Hung, and L.-Y. Li, “EZH2: a pivotal regulator in controlling cell differentiation,” American Journal of Translational Research, vol. 4, no. 4, pp. 364–375, 2012. View at Google Scholar · View at Scopus