Improved Protective Effect of Umbilical Cord Stem Cell Transplantation on Cisplatin-Induced Kidney Injury in Mice Pretreated with Antithymocyte Globulin
MSC treatment after ATG immunosuppression improves renal function and morphology as well as intestine morphology in BALB/cOlaHsd mice 4 days after cisplatin administration. (a) Representative micrographs of renal histology of healthy control mice and of mice treated with cisplatin and saline or MSCs and/or ATG (original magnification: ×200, periodic acid-Schiff (PAS) staining). (b) Serum concentration of blood urea nitrogen (BUN) and creatinine and caspase 3 score. Graphical results are expressed as mean ± SEM; ANOVA followed by Duncun multicomparison test: control versus all other groups. (c) Representative micrographs of intestine of healthy control mice and of mice treated with cisplatin and saline or MSCs and/or ATG (original magnification: ×200, Kreyberg-Jareg staining).
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