Stem Cells International / 2016 / Article / Tab 3

Research Article

Improved Protective Effect of Umbilical Cord Stem Cell Transplantation on Cisplatin-Induced Kidney Injury in Mice Pretreated with Antithymocyte Globulin

Table 3

Body weight, relative kidney weight, and renal function in BALB/cOlaHsd mice 4 days after cisplatin administration.

ControlMSCsATGATG + MSCsCISCIS + MSCsATG + CISATG + CIS + MSCs

Body weight (g), day 027.3 ± 0.6 25.6 ± 1.2 27.6 ± 2.2 27.4 ± 2.724.9 ± 0.724.6 ± 0.826.6 ± 0.426.9 ± 0.3
Body weight change (g) (day 0–day 4) 0.9 ± 0.40.2 ± 0.20.3 ± 0.40.5 ± 0.4 (−) 
5.1 ± 0.8
(−)
4.8 ± 0.5
(−)
4.8 ± 0.4
(−)
4.5 ± 0.9
Kidney relative weight ×1001.68 ± 0.051.69 ± 0.061.67 ± 0.051.74 ± 0.051.71 ± 0.271.67 ± 0.171.79 ± 0.191.51 ± 0.06
BUN (mmol/L)8.05 ± 0.777.43 ± 0.28.4 ± 0.476.95 ± 0.3743.87 ± 6.5742.7 ± 4.6340.26 ± 6.8431.34 ± 3.99
Creatinine (μmol/L)30.5 ± 0.7718.0 ± 0.218.25 ± 0.4731.5 ± 7.6383.67 ± 19.4348.0 ± 16.8342.0 ± 3.96 27.5 ± 1.91

ANOVA followed by Duncun multicomparison test; results are expressed as mean ± SEM; values with different superscript letters in rows are statistically different (). ATG + CIS + MSCs: cisplatin treated with single injection of MSCs pretreated with ATG, ATG + CIS: cisplatin, pretreated with ATG, ATG + MSCs: treated with single injection of MSCs pretreated with ATG, ATG: treated with ATG, CIS + MSCs: cisplatin treated with single injection of MSCs, CIS: cisplatin treated, and MSCs: treated with single injection of MSCs.

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