Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2016 (2016), Article ID 3595941, 9 pages
http://dx.doi.org/10.1155/2016/3595941
Research Article

In Vitro Characterization of Human Mesenchymal Stem Cells Isolated from Different Tissues with a Potential to Promote Complex Bone Regeneration

1Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary
2Creative Cell Ltd., Budapest, Hungary
3Department of Dentistry, Oral and Maxillofacial Surgery, University of Pécs Medical School, Pécs, Hungary
4National Blood Service, Budapest, Hungary
5Molecular Biophysics Research Group of the Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary

Received 8 July 2016; Accepted 19 October 2016

Academic Editor: Filiberto Mastrangelo

Copyright © 2016 Áron Szepesi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. A. König, D. D. Canepa, D. Cadosch et al., “Direct transplantation of native pericytes from adipose tissue: a new perspective to stimulate healing in critical size bone defects,” Cytotherapy, vol. 18, no. 1, pp. 41–52, 2016. View at Publisher · View at Google Scholar · View at Scopus
  2. L. Larsson, A. M. Decker, L. Nibali, S. P. Pilipchuk, T. Berglundh, and W. V. Giannobile, “Regenerative medicine for periodontal and peri-implant diseases,” Journal of Dental Research, vol. 95, no. 3, pp. 255–266, 2016. View at Publisher · View at Google Scholar
  3. M. Fröhlich, W. L. Grayson, L. Q. Wan, D. Marolt, M. Drobnic, and G. Vunjak-Novakovic, “Tissue engineered bone grafts: biological requirements, tissue culture and clinical relevance,” Current Stem Cell Research and Therapy, vol. 3, no. 4, pp. 254–264, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. Á. E. Mercado-Pagán, A. M. Stahl, Y. Shanjani, and Y. Yang, “Vascularization in bone tissue engineering constructs,” Annals of Biomedical Engineering, vol. 43, no. 3, pp. 718–729, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. P. A. Zuk, M. Zhu, H. Mizuno et al., “Multilineage cells from human adipose tissue: implications for cell-based therapies,” Tissue Engineering, vol. 7, no. 2, pp. 211–228, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Dominici, K. Le Blanc, I. Mueller et al., “Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement,” Cytotherapy, vol. 8, no. 4, pp. 315–317, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. X. Wei, X. Yang, Z.-P. Han, F.-F. Qu, L. Shao, and Y.-F. Shi, “Mesenchymal stem cells: a new trend for cell therapy,” Acta Pharmacologica Sinica, vol. 34, no. 6, pp. 747–754, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. M. L. Weiss, C. Anderson, S. Medicetty et al., “Immune properties of human umbilical cord Wharton's jelly-derived cells,” STEM CELLS, vol. 26, no. 11, pp. 2865–2874, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. A. J. Friedenstein, K. V. Petrakova, A. I. Kurolesova, and G. P. Frolova, “Heterotopic transplants of bone marrow,” Transplantation, vol. 6, no. 2, pp. 230–247, 1968. View at Publisher · View at Google Scholar · View at Scopus
  10. B. M. Seo, M. Miura, S. Gronthos et al., “Investigation of multipotent postnatal stem cells from human periodontal ligament,” The Lancet, vol. 364, pp. 149–155, 2004. View at Google Scholar
  11. V. Feisst, S. Meidinger, and M. B. Locke, “From bench to bedside: use of human adipose-derived stem cells,” Stem Cells and Cloning: Advances and Applications, vol. 8, pp. 149–162, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. V. N. Veryasov, A. M. Savilova, O. A. Buyanovskaya, M. M. Chulkina, S. V. Pavlovich, and G. T. Sukhikh, “Isolation of mesenchymal stromal cells from extraembryonic tissues and their characteristics,” Bulletin of Experimental Biology and Medicine, vol. 157, no. 1, pp. 119–124, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. Á. Szepesi, Z. Matula, A. Szigeti et al., “ABCG2 is a selectable marker for enhanced multilineage differentiation potential in periodontal ligament stem cells,” Stem Cells and Development, vol. 24, no. 2, pp. 244–252, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Shirmohammadi, M. T. Chitsazi, and A. Lafzi, “A clinical comparison of autogenous bone graft with and without autogenous periodontal ligament graft in the treatment of periodontal intrabony defects,” Clinical Oral Investigations, vol. 13, no. 3, pp. 279–286, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Tátrai, Á. Szepesi, Z. Matula et al., “Combined introduction of Bmi-1 and hTERT immortalizes human adipose tissue-derived stromal cells with low risk of transformation,” Biochemical and Biophysical Research Communications, vol. 422, no. 1, pp. 28–35, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Bodor, J. P. Nagy, B. Végh et al., “Angiotensin II increases the permeability and PV-1 expression of endothelial cells,” American Journal of Physiology—Cell Physiology, vol. 302, no. 1, pp. C267–C276, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. Á. Apáti, T. I. Orbán, N. Varga et al., “High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells,” Biochimica et Biophysica Acta (BBA)—Biomembranes, vol. 1778, no. 12, pp. 2700–2709, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Janeczek Portalska, A. Leferink, N. Groen et al., “Endothelial differentiation of mesenchymal stromal cells,” PLoS ONE, vol. 7, no. 10, article e46842, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Ciciarello, R. Zini, L. Rossi et al., “Extracellular purines promote the differentiation of human bone marrow-derived mesenchymal stem cells to the osteogenic and adipogenic lineages,” Stem Cells and Development, vol. 22, no. 7, pp. 1097–1111, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Maleki, F. Ghanbarvand, M. R. Behvarz, M. Ejtemaei, and E. Ghadirkhomi, “Comparison of mesenchymal stem cell markers in multiple human adult stem cells,” International Journal of Stem Cells, vol. 7, no. 2, pp. 118–126, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. O. G. Davies, P. R. Cooper, R. M. Shelton et al., “Isolation of adipose and bone marrow mesenchymal stem cells using CD29 and CD90 modifies their capacity for osteogenic and adipogenic differentiation,” Journal of Tissue Engineering, vol. 6, 2015. View at Publisher · View at Google Scholar
  22. M. S. Rodeheffer, K. Birsoy, and J. M. Friedman, “Identification of white adipocyte progenitor cells in vivo,” Cell, vol. 135, no. 2, pp. 240–249, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. M. T. Chung, C. Liu, J. S. Hyun et al., “CD90 (Thy-1)-positive selection enhances osteogenic capacity of human adipose-derived stromal cells,” Tissue Engineering—Part A, vol. 19, no. 7-8, pp. 989–997, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. Z. Gamie, R. J. MacFarlane, A. Tomkinson et al., “Skeletal tissue engineering using mesenchymal or embryonic stem cells: clinical and experimental data,” Expert Opinion on Biological Therapy, vol. 14, no. 11, pp. 1611–1639, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Yu, J. Long, J. Yu et al., “Analysis of differentiation potentials and gene expression profiles of mesenchymal stem cells derived from periodontal ligament and wharton's jelly of the umbilical cord,” Cells Tissues Organs, vol. 197, no. 3, pp. 209–223, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Torreggiani, G. Lisignoli, C. Manferdini et al., “Role of slug transcription factor in human mesenchymal stem cells,” Journal of Cellular and Molecular Medicine, vol. 16, no. 4, pp. 740–751, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. Z.-Y. Zhang, S.-H. Teoh, M. S. K. Chong et al., “Superior osteogenic capacity for bone tissue engineering of fetal compared with perinatal and adult mesenchymal stem cells,” Stem Cells, vol. 27, no. 1, pp. 126–137, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Kubo, M. Shimizu, Y. Taya et al., “Identification of mesenchymal stem cell (MSC)-transcription factors by microarray and knockdown analyses, and signature molecule-marked MSC in bone marrow by immunohistochemistry,” Genes to Cells, vol. 14, no. 3, pp. 407–424, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. N. P. Talele, J. Fradette, J. E. Davies, A. Kapus, and B. Hinz, “Expression of α-smooth muscle actin determines the fate of mesenchymal stromal cells,” Stem Cell Reports, vol. 4, no. 6, pp. 1016–1030, 2015. View at Publisher · View at Google Scholar · View at Scopus
  30. E. J. Gang, D. Bosnakovski, C. A. Figueiredo, J. W. Visser, and R. C. R. Perlingeiro, “SSEA-4 identifies mesenchymal stem cells from bone marrow,” Blood, vol. 109, no. 4, pp. 1743–1751, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. H. He, T. Nagamura-Inoue, H. Tsunoda et al., “Stage-specific embryonic antigen 4 in Wharton's jelly-derived mesenchymal stem cells is not a marker for proliferation and multipotency,” Tissue Engineering Part A, vol. 20, no. 7-8, pp. 1314–1324, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. S.-S. Yang, N.-R. Kim, K.-B. Park et al., “A phase I study of human cord blood-derived mesenchymal stem cell therapy in patients with peripheral arterial occlusive disease,” International Journal of Stem Cells, vol. 6, no. 1, pp. 37–44, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Iohara, L. Zheng, H. Wake et al., “A novel stem cell source for vasculogenesis in ischemia: subfraction of side population cells from dental pulp,” STEM CELLS, vol. 26, no. 9, pp. 2408–2418, 2008. View at Publisher · View at Google Scholar · View at Scopus