Transplanted Endothelial Progenitor Cells Improve Ischemia Muscle Regeneration in Mice by Diffusion Tensor MR Imaging

<div>Morphological changes and immunocytochemical analysis in mouse bone marrow-derived EPCs. (a) MNCs changed from globe-like shape to being thin and flat and then round and fusiform at day 7 (bar = 30 <i>μ</i>m). These cells were positive by indirect immunofluorescent staining for the markers of hematopoietic stem cells and progenitor cells, CD34, CD133, and CXCR4 (bar = 30 <i>μ</i>m). (b) The EPCs were able to take up Dil-labeled acetylated low-density lipoprotein (LDL) and bind the endothelial-specific lectin FITC-labeled lectin after 14 days in culture, which were colocalized in &gt;95% cell (bar = 30 <i>μ</i>m).</div>

Stem Cells International

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Figure 2: Transplanted Endothelial Progenitor Cells Improve Ischemia Muscle Regeneration in Mice by Diffusion Tensor MR Imaging 