Regenerative Therapy of Type 1 Diabetes Mellitus: From Pancreatic Islet Transplantation to Mesenchymal Stem Cells

<table class="algorithm-group"><tr><td><table class="algorithm" id="figbox1"><tr><td colspan="2">Shrinking motivation to donate organs</td></tr><tr><td colspan="2">Allocation of high-quality pancreas in an aging population</td></tr><tr><td colspan="2">Attack on intraportally transplanted islets by innate immune system components (Instant Blood</td></tr><tr><td colspan="2">mediated Inflammation Reaction IBMIR)</td></tr><tr><td colspan="2">Need to repeated transplantations within a few years due to little regenerating capacity</td></tr><tr><td colspan="2">No complete freedom from insulin shots</td></tr><tr><td colspan="2">Life-long immunosuppression</td></tr></table></td></tr></table>

<div>Detriments of cadaveric human islet transplantation.</div>

Stem Cells International

figbox1

Box 1

Box 1: Regenerative Therapy of Type 1 Diabetes Mellitus: From Pancreatic Islet Transplantation to Mesenchymal Stem Cells 