Stem Cells International

Review Article

Regenerative Therapy of Type 1 Diabetes Mellitus: From Pancreatic Islet Transplantation to Mesenchymal Stem Cells

Table 3

Overview of studies addressing ectopic transduction of genes to promote beta-cell differentiation in BM-MSC and AD-MSC. Resultant expression of key pancreatic transcription factors, hormones, and improvement of diabetes in vivo.
  Cell sourcePDX-1FoxA2/HNF3βNGN-3Pax-4Pax-6NeuroDIsl-1Glut-2GCKInsulinGlucagonSomatostatinC-peptideDTZ stainingGSIS in vitroGSIS in vivoAmeliorates diabetes
 Adipose tissue                 
Bahrebar et al. 2015 [62]LV-Pdx1+ND+NDNDNDNDNDND+NDNDND++NDND
Lee et al. 2013 [63]pAd-Pdx1-ZSGreen++NDNDND+ND+++NDND+ND++−
Boroujeni and Aleyasin 2013 [64]LV-Pdx1+ND+NDNDNDND+ND+++NDND+++
Lin et al. 2009 [65]LV-Pdx1+NDNDNDND+NDNDND++NDNDND+ND+
 Bone marrow                 
Jafarian et al. 2015 [66]miR-375, anti-miR-9+++NDNDNDND+ND++++++NDND
Allahverdi et al. 2015 [67]LV-Pdx1+NDNDNDNDNDNDNDND+NDND+ND+NDND
Limbert et al. 2011 [68]Pdx1-pDNA6/Ngn3-pcDNA3.1+ND+++++++++++ND−NDND
Limbert et al. 2011 [68]Pdx1-pDNA6+ND−++++++++++ND−NDND
Limbert et al. 2011 [68]Ngn3-pcDNA3.1+ND+++++++++++ND−NDND
Karnieli et al. 2007 [69]RV-Pdx1+ND−+Like basal−Like basal++++Like basal+ND+ND+