Hijacking the Cellular Mail: Exosome Mediated Differentiation of Mesenchymal Stem Cells

Figure 5

IHC of scaffold explant sections from in vivo implantation: all images are representative 3D reconstructions of z-stack confocal image slices. (a1, a2, and a3) represent sections from control, regular exosome, and osteogenic exosome treated samples, respectively, stained with pSTT antibody. (b1, b2, and b3) represent sections from control, regular exosome, and osteogenic exosome treated samples, respectively, stained with DMP1 antibody. (c1, c2, and c3) represent sections from control, regular exosome, and osteogenic exosome treated samples, respectively, stained with VEGF antibody. (d1, d2, and d3) represent sections from control, regular exosome, and osteogenic exosome treated samples, respectively, stained with BMP2 antibody. Except for BMP2, note the increase in the expression levels of proteins in the exosome treated samples.