Cancer Stem Cell Plasticity as Tumor Growth Promoter and Catalyst of Population Collapse

Figure 4

(a) Simulation snapshots of the biggest tumor at days for each considered plasticity event probability. : number of cancer stem cells; : number of cancer cells. Comparison of circularity (b), percent of quiescent cells (c), and cancer stem cells fraction in 200 μm proximity of tumor boundary (d) for different probabilities of plasticity event. Shown are means ±SD from 100 simulation runs (only successfully grown tumors are considered).

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