Review Article

MicroRNAs: From Female Fertility, Germ Cells, and Stem Cells to Cancer in Humans

Table 1

MiRNAs regulating pluripotency and differentiation of hESCs.

Genes related to pluripotencyReferences
OCT4NANOGSOX2KLF4LEFTYNR2F2

Maintenance of pluripotency
miR-203miR-203[82]

Regulation of stem cell renewal and differentiation
miR-200c[83]

Delay of differentiation, balance between differentiation and pluripotency
miR-302s[84]

Low in self-renewal and high during differentiation
miR-145miR-145miR-145[85]

Regulation of cell cycle genes in pluripotent stem cells
miR-302amiR-302a[86]

Balance between pluripotency and differentiation, NR2F2 critical for neural gene activation
miR-302miR-302[87]