Research Article
Monitoring the Bystander Killing Effect of Human Multipotent Stem Cells for Treatment of Malignant Brain Tumors
Figure 5
In vivo validation of BLI signal intensity and hMultistem survival in Hsd:Athymic-FoxN1nu mice. (a) Bioluminescence images of a representative animal that received 5 × 105 hMultistems (day 1) and was treated from day 2 to day 15 with either PBS or GCV (50 mg/kg). (b) Quantification of BLI signal intensities shows that (1) the stem cells were detectable by BLI, (2) stem cell survival was reduced in the environment of the host’s brain, and (3) no statistically significant difference in stem cell viability between the PBS and GCV receiving animals was detected. Number of animals was 6 per group.
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