Magnetic Nanoparticles for Targeting and Imaging of Stem Cells in Myocardial Infarction

Figure 7

(a) Prussian blue staining showing the proper labeling of rat CDCs with ferumoxytol (FHB), (b) serum cardiac troponin-I (sTnI) values after intracoronary injection of 500,000 cells into noninfarcted rats, (c) T weighted MRI images showing higher cell retention in magnetic targeted samples (according to their dark signals which are shown by red arrows) 24 h after delivery of CDCs into rats myocardial infarcted model, (d) fluorescent imaging demonstrating the existence of labelled cells (in red, as the cells were transduced by red fluorescent protein) in rat in hearts and lungs, and (e) SRY qPCR quantitation of cell retention (reproduced with permission [44]). indicates statistical significance with .

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