Review Article

Stem Cells of Dental Origin: Current Research Trends and Key Milestones towards Clinical Application

Table 1

Marker expression in dental MSCs (SHED, DPSCs, and SCAP) and factors identified in their secretomes.

Dental MSCsPositive markersNegative markersFactors in secretome involved in angiogenesisFactors in secretome involved in neurogenesis

Stem cells from Human Exfoliatd Deciduous teeth (SHED)CD90, CD73, CD105, CD146, STRO-1, CD44, CD13
Nestin, DCX, βΙΙΙ-tubulin, NeuN, GFAP, S-100, A2B5, CNPase
Nanog, Oct3/4, SSEAs (-3, -4)
CD11b
CD45
CD34
CD14
CD19
CD43
VEGF-A, VEGF-C, EG-VEGF (PK-1), HGF, IGF-1, FGF-2, SDF-1, SCF, EGF, TIMP-1, -2, MMP-2, -3, -9, MCP-1, ANG, TGF-bBDNF, GDNF, MCP-1, ED-Siglec-9, IL-6, NRCAM, GDF-15, NCAM-1, TACE, Nidogen-1 NRG-1, TIMP-1, -2, HGF, SCF, MMP-2, -3, -9, decorin, IL-22, IL28A, IL-29, osteopontin, SCF, ANG, VEGF-A, EG-VEGF, VEGF-C, growth hormone, insulin, PIGF, TGF-b

Dental Pulp Stem Cells (DPSCs)CD90, CD73, CD105, CD146, STRO-1, CD106, CD29, CD49, CD51, CD61, CD166, ALDH1, 3G5, CD44, CD9, CD10 CD13, CD59, MSCA-1, CD81, CD24
CD271/NGFR, Nestin, DCX, βΙΙΙ-tubulin, NeuN, GFAP, S-100, A2B5, CNPase, musashi-1, p75, snail-1, -2, slug, Sox-9
Nanog, Oct3/4, SSEAs (-1, -3, -4, -5), Notch-1, -2, -3
CD45
CD34
CD14,
CD19 CD31, CD117, CD133
HLA-DR
VEGF, uPA, IL-8, TSP-1, IGFBP-3, TIMP-1, -4, MMP-9, PAI-1 (serpin E1), endostatin, ANGPT-1, ANG, DPPIV, EDN-1, PTX-3, PEDF (serpin F1), PDGF-AA and PDGF-AB/BB, MCP-1NGF, BDNF, NT-3, CNTF, GDNF, MCP-1, VEGF, FGF-2, PDGF-AA and PDGF-AB/BB, MMP-9, ANG, TIMP-1, -4

Stem Cells from Apical Papilla (SCAP)CD90, CD73, CD105, CD146, STRO-1, CD106, CD29, CD49, CD51, CD61, CD166, ALDH1, 3G5, CD44, CD9, CD10 CD13, CD59, MSCA-1, CD34, CD81, CD24, c-Kit
CD271/NGFR, Nestin, NSE, CNPase, musashi-1, p75, snail-1, -2, slug, Sox-9
Nanog, Oct3/4, SSEAs (-1, -3, -4, -5), TRA-1-60-, TRA-1-81, Notch -2, -3
CD14
CD18
CD34
CD45
CD117
CD150
ANGPT-1, ANG, DPPIV, EDN-1, PTX-3, PEDF (serpin F1), IGFBP-1, -2, -3, TIMP-1, -4, TSP-1, VEGF, uPA, Activin A, HGF, FGF-7, PIGF (serpin E1), TGFb, CXCL-16, persephin, NRG1-b1, MCP-1MDK, NEGF-1 (PTN), NEGF-2, CXCR4, MANF, AHNAK, NRP2, ANG, TIMP-1, -4, CXCL-16, NRG1-b1, MCP-1