The Aryl Hydrocarbon Receptor Relays Metabolic Signals to Promote Cellular Regeneration

Figure 1

Ubiquitous AHR expression in iPSC and HSC regardless of potency and self-renewal activity. (a-b) AHR is expressed in (a) iPSC (OCT3/4+) and (b) cells from iPSC-derived embryoid bodies differentiating into hematopoietic lineages. Blue dots/areas correspond to fluorescence minus one (FMO) gating controls. (c-d) AHR is expressed in mobilized peripheral blood which is known to be enriched for (c) HSC and (d) leukemic cells with abnormal self-renewing activity.

(a) Human induced pluripotent stem cells

(b) Hematopoietic differentiation from iPSC

(c) Human mobilized peripheral blood

(d) Human peripheral blood from leukemic patients