Survivin Improves Reprogramming Efficiency of Human Neural Progenitors by Single Molecule OCT4

Figure 7

The expression of Survivin was decreased with ES cell differentiation. (a) Expression of Survivin was downregulated with ES cell differentiation with Retinoic Acid (RA). The cells of 0 h, 24 h, 36 h, 48 h, and 72 h were collected for Western blot analysis. The proteins of SOX2, OCT4, and Survivin were analyzed in RA-treated differentiation and β-actin as housekeeping control. (b) The change of Survivin mRNA levels in the process of RA-treated differentiation for ES cells. The expressions of mRNA decreased gradually and sharply with prolonged RA-treatment time.

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