Stem Cells International

Stem Cells International / 2016 / Article
Special Issue

Tissue-Derived Stem Cell Research

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Editorial | Open Access

Volume 2016 |Article ID 4801953 |

Ming Li, Kequan Guo, Dong Hyun Kim, Luca Vanella, "Tissue-Derived Stem Cell Research", Stem Cells International, vol. 2016, Article ID 4801953, 1 page, 2016.

Tissue-Derived Stem Cell Research

Received09 Dec 2015
Accepted13 Dec 2015
Published17 Jan 2016

Tissue-derived stem cells (TDSCs) are undifferentiated cells, presented in tissues such as bone marrow, blood vessels, and adipose tissues and with the ability to repair damaged areas by generation of new cells and tissues. TDSCs have proven to be a feasible source of cells for tissue regeneration medicine in recent experimental and clinical studies. Mesenchymal stem cells revealed potential benefits in atherosclerosis [1] and endothelial progenitor cells reduced lung damage and improved lung function [2]. Moreover, there were some reports that suggested that adipose derived stem cells may improve injured lung function [3], infracted heart function [4], and injured kidney and its function [5]. Regulation of the process to successfully trigger proper differentiation into the desired cell types is important. Moreover, it is more important to confirm safety of transplantation when stem cells are used to treat diseases.

In the present special issue, the significance and possible clinical applications of TDSCs were presented. Some manuscripts described important biochemical cascade underlying the processes of osteogenesis, adipogenesis, angiogenesis, and their possible applications in new therapy development. All findings and experiences of TDSCs research will open up new possibilities for the treatment of various diseases and extend the human life span.

Ming Li
Kequan Guo
Dong Hyun Kim
Luca Vanella


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  2. A. Güldner, T. Maron-Gutierrez, S. C. Abreu et al., “Expanded endothelial progenitor cells mitigate lung injury in septic mice,” Stem Cell Research & Therapy, vol. 6, article 230, 2015. View at: Publisher Site | Google Scholar
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  4. L. L. Bagno, D. Carvalho, F. Mesquita et al., “Sustained IGF-1 secretion by adipose-derived stem cell improves infarcted heart function,” Cell Transplantation, 2015. View at: Publisher Site | Google Scholar
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Copyright © 2016 Ming Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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