Tumor Budding, Micropapillary Pattern, and Polyploidy Giant Cancer Cells in Colorectal Cancer: Current Status and Future Prospects

Figure 1

Tumor budding, PGCCs, and micropapillary carcinoma pattern in CRCs. ((a) and (b)) PGCCs with budding appear in minimally differentiated CRCs. Black arrows indicate PGCCs and red arrows indicate daughter cells generated by PGCCs (HE, ×200). (c) Micropapillary patterns appear in minimally differentiated CRC (HE, ×100). (d) PGCCs appear in micropapillary patterns (HE, ×100, black arrows). ((e) and (f)) Single PGCCs with their budding daughter cells in CRCs; and the structure is similar to tumor budding. Black arrows indicate PGCCs and red arrows indicate daughter cells budded by PGCCs (HE, ×200).

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