The Effect of MSCs Derived from the Human Umbilical Cord Transduced by Fibroblast Growth Factor-20 on Parkinson’s Disease

Figure 3

TH expressions in PD mice after cell treatment. (a, b) TH immunohistochemistry staining results showed that the number of TH-positive cells greatly decreased in the model group (scale bar = 50 μm), and the cells were not neatly arranged, axons and dendrites became thinner and broken, anastomosing networks of axons became loose, and infiltration of tangled glial cells was seen (arrows). After hUC-MSC and hUC-MSC-FGF-20 treatment, TH-positive cells stained darker and the number of the cells was obviously increased. (c, d) WB results showed that tendency of TH expression changes in the corpus striatum was consistent with immunohistochemistry results (, the normal group versus the model group; , the model group versus MSC and MSC-FGF-20 group; , MSC group versus MSC-FGF-20 group).

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