The Effect of MSCs Derived from the Human Umbilical Cord Transduced by Fibroblast Growth Factor-20 on Parkinson’s Disease

<div>The level of DA in the corpus striatum of PD mice. DA level was greatly decreased in the model group, whereas it was obviously increased after hUC-MSC and hUC-MSC-FGF-20 treatments (<svg height="15.0052pt" id="M21" style="vertical-align:-3.834001pt" version="1.1" viewbox="-0.0498162 -11.1712 52.0027 15.0052" width="52.0027pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M554 -9C527 -24 450 -47 393 -47C190 -47 121 88 121 219C121 405 248 538 435 538C571 538 672 461 672 324C672 188 591 120 529 119C504 118 499 130 509 181C524 263 542 344 558 409C546 409 536 411 521 414C509 417 485 422 471 422C409 421 354 390 309 348C250 292 227 214 227 159C227 100 252 74 276 74C323 74 416 153 448 201L450 200L440 146C431 103 432 74 486 74C622 74 725 187 725 323C725 460 623 581 440 581C246 581 54 444 53 208C53 4 199 -96 359 -96C429 -96 496 -82 566 -42L554 -9ZM430 378C449 378 471 373 484 366C478 338 469 292 459 260C398 176 343 141 327 141C315 141 306 149 306 183C306 246 335 317 364 348C381 366 403 378 430 378Z" id="g50-65"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="764" vert-adv-y="764"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,7.477,-1.651)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z" id="g113-113"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="593" vert-adv-y="593"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,18.846,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z" id="g117-91"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,30.109,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,36.349,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z" id="g113-47"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="228" vert-adv-y="228"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,39.313,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,45.553,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z" id="g113-50"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg>, the normal group versus the model group; 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Stem Cells International

fig4

Figure 4

Figure 4: The Effect of MSCs Derived from the Human Umbilical Cord Transduced by Fibroblast Growth Factor-20 on Parkinson’s Disease 