Stem Cells International / 2016 / Article / Tab 2

Research Article

Prognostic Factors on the Graft-versus-Host Disease-Free and Relapse-Free Survival after Adult Allogeneic Hematopoietic Stem Cell Transplantation

Table 2

Prognostic factors for 1-year GRFS after adult allogeneic HSCT.

FactorsEvents%Univariate analysisMultivariate analysis
HR95% CI valueHR95% CI value

Age at HSCT
351396949.61.4461.087–1.9230.0111.0680.783–1.4560.679
3523815163.4
EBMT risk score
21556743.22.1971.647–2.913<0.0011.8971.385–2.599<0.001
222215368.9
Gender
 Female1688450.01.4191.081–1.8630.0121.3100.994–1.7250.055
 Male20913665.1
Disease type
 Nonmalignant 481633.32.2441.348–3.7350.0021.7631.048–2.9660.033
 Malignant32920462.0
Disease type
 Myeloid17611163.10.8350.641–1.0880.182
 Nonmyeloid20110954.2
Conditioning
 Nonmyeloablative1297255.81.0840.818–1.4360.576
 Myeloablative24814859.7
Conditioning
 Others25214256.31.2120.920–1.5980.172
 12 Gy TBI based1257862.4
Conditioning
 Others30316855.41.4911.092–2.0360.0121.1340.818–1.5740.450
 Fludarabine based745270.2
Donor type
 Matched sibling18111161.31.0050.771–1.3090.971
 Others19610955.6
Type 2 DM
 No36221058.01.3390.710–2.5260.367
 Yes151066.7
Smoking history
  No 35320457.81.3480.810–2.2420.250
  Yes241666.7
Posttransplant CMV reactivation
 No18910153.41.3351.024–1.7410.0331.1600.884–1.5220.285
 Yes18811963.3
PTLD
 No36321258.41.0470.517–2.1200.899
 Yes14857.1

CI: confidence interval; HR: hazard ratio; EBMT: European Group for Blood and Marrow Transplantation; HSCT: hematopoietic stem cell transplantation; PTLD: posttransplant lymphoproliferative disorders; DM: diabetes mellitus; CMV: cytomegalovirus; TBI: total body irradiation.
Factors with statistical significance () upon univariate analysis were included in multivariate analysis.

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