Stem Cells International / 2016 / Article / Tab 3

Research Article

Prognostic Factors on the Graft-versus-Host Disease-Free and Relapse-Free Survival after Adult Allogeneic Hematopoietic Stem Cell Transplantation

Table 3

Prognostic factors for 2-year GRFS after adult allogeneic HSCT.

FactorsEvents%Univariate analysisMultivariate analysis
HR95% CI valueHR95% CI value

Age at HSCT
351397453.21.4521.102–1.9130.0081.0800.799–1.4590.617
3523816067.2
EBMT risk score
21557347.12.1651.640–2.857<0.0011.8351.354–2.486<0.001
222216172.7
Gender
 Female1688953.01.4561.118–1.8960.0051.3481.032–1.7610.028
 Male20914569.4
Disease type
 Nonmalignant 481633.32.4951.500–4.149<0.0011.9791.178–3.3240.010
 Malignant32921866.3
Disease type
 Myeloid17611766.50.8360.647–1.0810.172
 Nonmyeloid20111758.2
Conditioning
 Nonmyeloablative1297558.11.1350.863–1.4940.365
 Myeloablative24815964.1
Conditioning
 Others25215059.51.2460.953–1.6270.107
 12 Gy TBI based1258467.2
Conditioning
 Others30317959.11.4941.104–2.0220.0091.1150.811–1.5320.503
 Fludarabine based745574.3
Donor type
 Matched sibling18111965.70.9760.755–1.2610.851
 Others19611558.7
Type 2 DM
 No36222461.91.2600.699–2.3750.474
 Yes151066.7
Smoking history
 No 35321661.21.4150.903–2.3640.122
 Yes241875.0
Posttransplant CMV reactivation
 No18710757.21.3491.042–1.7460.0231.1700.899–1.5230.242
 Yes19012766.8
PTLD
 No36222862.91.4630.651–3.2920.357
 Yes15640.0

CI: confidence interval; HR: hazard ratio; EBMT: European Group for Blood and Marrow Transplantation; HSCT: hematopoietic stem cell transplantation; PTLD: posttransplant lymphoproliferative disorders; DM: diabetes mellitus; CMV: cytomegalovirus; TBI: total body irradiation.
Factors with statistical significance () upon univariate analysis were included in multivariate analysis.

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