Lavandula angustifolia Extract Improves the Result of Human Umbilical Mesenchymal Wharton’s Jelly Stem Cell Transplantation after Contusive Spinal Cord Injury in Wistar Rats

Figure 3

HUMSCs transplantation and administration of L. angustifolia improved histomorphological results, decreased cavity area (a), and increased the number of VHMNs (b) in the rat spinal cord contusion model. Intraperitoneal administration of L. angustifolia extract daily for 14 consecutive days after injury significantly improved histomorphological results including cavity area and VHMNs results. Data are represented as the mean ± S.E.M. , , and  show significant differences of HUMSCs, HUMSCs + Lav 100, 200, and 400 compared to SCI (control 1) group (, , and , resp.). shows significant differences between HUMSCs + Lav 400 and HUMSCs (control 2) (). Cavity area significantly decreased in HUMSCs and HUMSCs + Lav-treated groups (a) (Per 35625 μm²). Number of ventral horn motor neurons significantly increased in HUMSCs and HUMSCs + Lav-treated groups (b) (Per 5700 μm²).

(a) Cavity area

(b) Number of ventral horn motor neurons