tPA-MMP-9 Axis Plays a Pivotal Role in Mobilization of Endothelial Progenitor Cells from Bone Marrow to Circulation and Ischemic Region for Angiogenesis

Figure 11

Protein expression of vascular endothelial growth factor (VEGF) in ischemic quadriceps at day 14 after critical limb ischemia (CLI) induction. (a) At sham control (SC) treatment condition, VEGF did not differ among four groups, . (b) At CLI subgroup, groups with different symbols (, , , and ), . (c) At SC + tPA subgroup, VEGF did not differ among four groups, . (d) At CLI + tPA subgroup, groups with different symbols (, , , and ), . All statistical analyses were performed by one-way ANOVA followed by Bonferroni multiple comparison post hoc test. tPA = tissue plasminogen activator. for each group.

(a)

(b)

(c)

(d)