tPA-MMP-9 Axis Plays a Pivotal Role in Mobilization of Endothelial Progenitor Cells from Bone Marrow to Circulation and Ischemic Region for Angiogenesis

Figure 15

Matrix metalloproteinase- (MMP-) 9 activity in BM by 18 h after CLI procedure. (a) Zymography analysis of matrix metalloproteinase- (MMP-) 9 activity in BM of four groups. No MMP-9 activity was identified in M M and M B groups. On the other hand, MMP-9 activity was observed in B B and B M groups. (b) (1) Zymography analysis of pro-MMP-9 activity in B B group of different treatment condition (white bar chart), α versus β, . (2) Zymography analysis of active form of MMP-9 in B B group of different treatment condition (black bar chart), subgroups with different symbols (, , , and ), . Symbols (, , , and ) indicate significance (at 0.05 level). for each group. (c) (1) Zymography analysis of pro-MMP-9 activity in B M group of different treatment condition (white bar chart), α versus β, . (2) Zymography analysis of active form of MMP-9 in B M group of different treatment condition (black bar chart), subgroups with different symbols (, , , and ), . for each group.

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