tPA-MMP-9 Axis Plays a Pivotal Role in Mobilization of Endothelial Progenitor Cells from Bone Marrow to Circulation and Ischemic Region for Angiogenesis

Figure 9

Protein expression of stromal cell-derived factor- (SDF-) 1α in ischemic quadriceps at day 14 after critical limb ischemia (CLI) induction. (a) At sham control (SC) treatment condition, SDF-1α did not differ among four groups, . (b) At CLI subgroup, groups with different symbols (, , , and ), . (c) At SC + tPA treatment condition, SDF-1α did not differ among four groups, . (d) At CLI + tPA subgroup, groups with different symbols (, , , and ), . All statistical analyses were performed by one-way ANOVA followed by Bonferroni multiple comparison post hoc test. tPA = tissue plasminogen activator. for each group.

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