Formation of Tumorspheres with Increased Stemness without External Mitogens in a Lung Cancer Model

<div>DIG downregulates Sox2 expression likely independent of the PI3K/AKT pathway. Expression of Sox2, pAKT, AKT, and GAPDH in untreated and DIG-treated H460 parental cells (P) and lung tumorspheres (LTSs) grown in SFM without external mitogens for 14 days.</div>

Stem Cells International

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Figure 4

Figure 4: Formation of Tumorspheres with Increased Stemness without External Mitogens in a Lung Cancer Model 