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Stem Cells International
Volume 2016, Article ID 5791317, 11 pages
http://dx.doi.org/10.1155/2016/5791317
Research Article

Cellular Origins of Regenerating Nodules and Malignancy in the FAH Model of Liver Injury after Bone Marrow Cell Transplantation

1Department of Pediatrics, Second Hospital of Shandong University, Jinan 250033, China
2Department of Medicine, University of Washington, Seattle, WA 98195, USA

Received 20 July 2015; Accepted 4 October 2015

Academic Editor: Laura Lasagni

Copyright © 2016 Pei-Rong Wang and Yi Li. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplemental figure 1: Donor DNA levels in bone marrow, spleens. 1-1: Southern blot analysis of EcoRV-digested genomic DNAs and probed for ROSAnZ sequences from mice ROSAnZ (Donor) and Fah-/- (recipients) genotypes in Group 1. Percentage of donor DNA levels in bone marrow of donors (A), bone marrow of recipients (B), spleen of donors (C) and spleens of recipients (D). The value presents as mean ± SEM. 1-2: Southern blot analysis of EcoRV-digested genomic DNAs and probed for Fah sequences from mice with wild-type C57Bl/6 (Donor) and Fah-/- - ROSAnZ (recipients) genotypes in Group 2. Percentage of donor DNA levels in bone marrow of donors (A), bone marrow of recipients (B), spleen of donors (C) and spleens of recipients (D). The value presents as mean ± SEM, (n ≥20).

  1. Supplementary Material