Research Article
Cellular Origins of Regenerating Nodules and Malignancy in the FAH Model of Liver Injury after Bone Marrow Cell Transplantation
| Weeks after BMT | Weeks off NTBC | Maximum # of cells per nodule or % regenerating liver | Density of BrdU+ cells in Fah+ regenerating nodule (mm2) |
| 1 | 1 | 0 | | 2 | 2 | 0 | | 3 | 3 | 1 | | 4 | 3 | 4 | | 5 | 4 | 5 | | 6 | 5 | 10 | | 7 | 6 | 15 | | 8 | 7 | 20 | 38.5 ± 16.9 | 10 | 8 | 50 | | 13 | 11 | 3–5% | 44.5 ± 16.7 | 18 | 15 | 15–25% | 27.7 ± 16.1 | 23 | 19 | 20–30% | | 28 | 23 | 15–30% | 1.89 ± 0.51 | 32 | 27 | 15–30% | 0.39 ± 0.23 |
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Donor-derived cells repopulate the livers of transplanted mice in Group 1. The value is presented as mean ± SD ().
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