Ciprofloxacin Improves the Stemness of Human Dermal Papilla Cells

Figure 6

Schematic diagram summarizes the effects of CIP for improvement of the stemness in human DPCs. CIP improved the stemness of human DPCs through Akt activation which accounts for GSK3β inactivation, resulting in the increase of cellular β-catenin. As a consequence, β-catenin accumulates in cytoplasm and translocates into nucleus leading to stimulation of target genes, including transcription factors associated with EMT and self-renewal that might exert the stemness sustaining effect of CIP.