Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies

Figure 1

Epigenetic reprogramming of MuSCs and FAPs during differentiation. MuSCs adopt a chromatin permissive structure on muscle genes in which MyoD and BAF60c-based SWI/SNF complex promote transcription (on the top). FAPs differentiation into adipocytes is mediated by BAF60a/b-based SWI/SNF complex (on the bottom). HDACi treatment in dystrophic muscles activates a myomiR/MyoD/BAF60c network that, switching the BAF60 subunits assembled in the SWI/SNF complex, reprograms FAPs toward the acquisition of a myogenic phenotype.