Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia

Table 1

Study characteristic report.

Author	Year of publish	Numbers; (SCs/Con)	Age	Type of stroke; Acute/chronic	Gender; Male/female	Type of interventions		Cells dose; ×10^6	Route of injection	Follow-up; (month)	Outcome effect indicators
						Stem cell	Control
Bang et al. [9]	2005	5/25	63.0 ± 7.5	Acute	18/12	MSC	Routine	100	Intravenous	12	Barthel
Sun et al. [10]	2008	20/22	57.8 ± 8.9	X	32/10	MSC	Routine	X	Intravenous	3	NIHSS
Niu et al. [11]	2010	16/20	56 ± 7	Chronic	22/14	NSC	Routine	X	Subarachnoid	6	FIM
Bhasin et al. [12]	2011	6/6	42	Chronic	8/4	MSC	Routine	50–60	Intravenous	6	FMA, Barthel
Deng et al. [13]	2012	15/15	X	Acute	X	MSC	Routine	10–50	Intravenous	1	NIHSS
He [14]	2012	20/18	56.4 ± 7.9	X	23/15	MSC	Routine	100	Intravenous	3	NIHSS
Bhasin et al. [15]	2012	12/12	46.5	Chronic	X	MNC	Routine	50–60	Intravenous	6	FMA, Barthel
Xiao [16]	2013	78/82	56.9 ± 9.2	X	103/57	NSC	Routine	8000	Subarachnoid	X	FIM
Bhasin et al. [17]	2013	14/20	45.1 ± 12.1	Chronic	32/8	MNC	Routine	50–60	Intravenous	6	FMA, Barthel
		6/20	45.1 ± 12.1	Chronic	32/8	MSC	Routine	50–60	Intravenous	6	FMA, Barthel
Liu et al. [18]	2014	29/29	55.3 ± 3.6	Acute	38/20	MSC	Routine	100	Subarachnoid	3	NIHSS, Barthel, FMA
Xie et al. [19]	2014	30/30	51.4 ± 7.2	Acute	37/23	MSC	Routine	X	Subarachnoid	6	NIHSS, Barthel
Chen et al. [20]	2014	15/15	50.1 ± 7.7	Chronic	20/10	PBSC	Routine	3–8	Stereotactic	12	NIHSS
Prasad et al. [21]	2014	60/60	50.7 ± 11.6	Acute	77/43	MSC	Routine	280.75	Intravenous	12	NIHSS, Barthel
Zhang et al. [22]	2015	14/28	57.2 ± 7.3	X	34/26	NSC	Routine	40	Intravenous	6	FIM
		18/28	56.9 ± 7.5	X	34/26	NSC	Routine	40	Subarachnoid	6	FIM
Shen [23]	2015	16/16	52 ± 10.4	Acute	X	UC-MSC	Routine	1000	Intra-carotid	3	FIM
Cai et al. [24]	2015	21/21	61.4 ± 6.7	Chronic	27/15	MSC	Routine	150–600	Intravenous	6	FIM, FMA, Barthel

MSC: mesenchymal stem cell; NSC: neural stem cell; MNC: bone marrow mononuclear stem cells; PBSC: peripheral blood stem cell; UC-MSC: umbilical cord blood mesenchymal stem cell; X: unknown.