The Characteristics Variation of Hepatic Progenitors after TGF-β1-Induced Transition and EGF-Induced Reversion

Figure 1

Seven-day EGF incubation allows for time-dependent reversal of the TGF-β1-induced myofibroblast phenotype in hepatic oval cells. (a) After 7-day EGF incubation, the morphology of 16-day TGF-β1-pretreated cells returned to an epithelial morphology similar to the control oval cells. ((b) and (c)) Incubation of 16-day TGF-β1-pretreated cells for 7 days with EGF reduced the mRNA transcription and protein expression of α-SMA and collagen I in a time-dependent manner.

(a)

(b)

(c)